2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine 2,3-Dioxygenase (IDO)

(IDO)

Indoleamine 2,3-Dioxygenase (IDO)

Related Products

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Indoleamine 2, 3-dioxygenase (IDO) is an inflammatory cytokine-inducible rate-limiting enzyme of the tryptophan (Trp) catabolism, which is involved in the inhibition of intracellular pathogen replication as well as in immunomodulation. To date, three types of tryptophan-metabolizing enzymes have been identified: IDO1, IDO2 and tryptophan 2,3-dioxygenase 2.

IDO is an intracellular enzyme that is constitutively expressed in several human and mouse cells. Being present in innate immune cells, such as Mos and dendritic cells (DCs), IDO catalyzes the initial rate-limiting step of tryptophan (Trp) catabolism, thus leading to the production of immunoregulatory catabolites (collectively known as kynurenines).

The IDO gene promoter contains multiple sequence elements that confer responsiveness to proinflammatory mediators, thereby demonstrating the strong correlation between inflammation and induced IDO expression.

Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

Indoleamine 2,3-Dioxygenase (IDO) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173067
    IDO1 ligand-1
    IDO1 ligand-1 is the target protein ligand of PROTAC NU227326 (HY-173066). NU227326 can be used to degrade IDO1.
    IDO1 ligand-1
  • HY-144273
    IDO1-IN-13
    		Inhibitor
    IDO1-IN-13 (compound 27a) is a potent IDO1 inhibitor with an IC50 of 61.6 nM. IDO1-IN-13 has cellular IDO1 inhibition (HeLa EC50= 30 nM). IDO1-IN-13 decreases 51% of the kyn/trp ratio in SK-OV-3 xenograft tumor tissues.
    IDO1-IN-13
  • HY-158334
    NDs-IN-1
    		Inhibitor
    (Neurodegenerative diseases) NDs-IN-1 (Compound 3g) inhibits the activities of key enzymes such as hBACE-1, hAChE and hMAO-B. NDs-IN-1 is a novel non-covalent multi-target inhibitor. NDs-IN-1 is mainly used in the study of neurodegenerative diseases.
    NDs-IN-1
  • HY-144778
    IDO1/TDO-IN-1
    		Inhibitor
    IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway.
    IDO1/TDO-IN-1
  • HY-163520
    IDO1-IN-24
    		Inhibitor
    IDO1-IN-24 (compound 2c) inhibits IDO1 production in cell-based assay with an IC50 value of 17 μM.
    IDO1-IN-24
  • HY-173023
    IDOi-Pt(IV) prodrug-1
    		Inhibitor
    IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug. IDOi-Pt(IV) prodrug-1 inhibits IDO expression. IDOi-Pt(IV) prodrug-1 induces apoptosis, decreases the mitochondrial membrane potential, inhibits tumor cell migration and invasion. IDOi-Pt(IV) prodrug-1 induces reactive oxygen species-mediated endoplasmic reticulum stress and secretion of damage-associated molecular patterns (DAMPs), thereby presenting immunogenic cell death (ICD) effects. IDOi-Pt(IV) prodrug-1 has high-efficiency and low-toxicity antitumor effects compared to Cisplatin (HY-17394).
    IDOi-Pt(IV) prodrug-1
  • HY-151886
    NU223612
    		Inhibitor
    NU223612 is a potent PROTAC (PROTACs) that degrades indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a Kd of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB).
    NU223612
  • HY-154387
    1-Isopropyltryptophan
    		Inhibitor
    1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA.
    1-Isopropyltryptophan
  • HY-144465
    IDO1-IN-15
    		Inhibitor
    IDO1-IN-15 is a potent IDO1 inhibitor (IC50=127 nM). IDO1-IN-15 has comparable potency against IDO1 enzyme in vitro with Epacadostat.
    IDO1-IN-15
  • HY-N0110R
    Palmatine chloride (Standard)
    		Inhibitor
    Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.
    Palmatine chloride (Standard)
  • HY-168092
    VS-15
    		Inhibitor
    VS-15, a IDO1 inhibitor, selectively binds the heme-free form of IDO1. VS-15 is described as an iNOS inhibitor based on the reduction of NO production.
    VS-15
  • HY-N11451
    Lacto-N-fucopentaose III
    		Activator
    Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation.
    Lacto-N-fucopentaose III
  • HY-172874
    TDO-IN-2
    		Inhibitor
    TDO-IN-2 is an orally active TDO inhibitor (IC50: 1.25 μM). TDO-IN-2 has antitumor activity in the Hepa1-6 hepatocellular carcinoma allograft mouse model. TDO-IN-2 has synergistic effects with the PD-1/PD-L1 inhibitor BMS-202 (HY-19745) and can be used to study tumor immune tolerance.
    TDO-IN-2
  • HY-161348
    AT-0174
    		Inhibitor
    AT-0174 is an orally active dual inhibitor of IDO1/TDO2 (tryptophan 2,3-dioxygenase-2) with IC50 values of 0.17 and 0.25 μM, respectively. AT-0174 has antitumor activity.
    AT-0174
  • HY-145355
    IDO1-IN-12
    		Inhibitor
    IDO1-IN-12 is a potent and orally available IDO1 inhibitor.
    IDO1-IN-12
  • HY-149982
    IDO1-IN-22
    		Inhibitor
    IDO1-IN-22 (Compound 3) is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM). IDO1-IN-22 has excellent antitumor efficacy in LLC xenograft model, as well as desirable pharmacokinetic (PK) profile.
    IDO1-IN-22
  • HY-N0736R
    Coptisine chloride (Standard)
    		Inhibitor
    Coptisine (chloride) (Standard) is the analytical standard of Coptisine (chloride). This product is intended for research and analytical applications. Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6 μg/mL and can be used for influenza A (H1N1) infection.
    Coptisine chloride (Standard)
  • HY-130607
    IDO1-IN-2
    		Inhibitor
    IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.
    IDO1-IN-2
  • HY-N0707S
    (S)-Indoximod-d3
    		Inhibitor ≥99.0%
    (S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2][3].
    (S)-Indoximod-d<sub>3</sub>
  • HY-139653
    IDO-IN-14
    		Inhibitor
    IDO-IN-14 is an IDO inhibitor with an IC50 value of 0.6928 nM.
    IDO-IN-14
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Indoleamine 2,3-Dioxygenase (IDO) Isoform Comparison

IDO1

IDO2

IDO

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Indoleamine 2,3-Dioxygenase (IDO) Degraders & Inhibitors
Product NameIDO1IDO2IDOPurity    
Epacadostat
IDO1, IC50: 71.8 nM
  99.66%
Indoximod  
IDO, Ki: 19 μM
99.85%
NU227326
IDO1, DC50: 4.5 nM
  
IDO1/TDO-IN-8
IDO1, EC50: 0.33 μM
  
Linrodostat
IDO1, IC50: 1.1 nM
  99.81%
Palmatine chloride
IDO-1, IC50: 3 μM (HEK 293-hIDO-1)
IDO-1, IC50: 157 μM (rhIDO-1)
  99.81%
PF-06840003
IDO-1
  99.87%
Coptisine chloride  
IDO, IC50: 6.3 μM
IDO, Ki: 5.8 μM
99.73%
(Rac)-Indoximod  
IDO
99.18%
Navoximod  
IDO, EC50: 75 nM
IDO, Ki: 7 nM
99.99%
IDO-IN-7
IDO1, IC50: 38 nM
  99.80%
DP00477
IDO1, IC50: 7.0 μM
  99.03%
Palmatine hydroxide
IDO-1, IC50: 3 μM (HEK 293-hIDO-1)
IDO-1, IC50: 157 μM (rhIDO-1)
  99.64%
IDO1/TDO-IN-4
IDO1, IC50: 3.53 μM
  99.23%
LY-3381916
IDO1
  99.92%
GNF-PF-3777 
rhIDO2, IC50: 1.8 μM
rhIDO2, Ki: 0.97 μM
 98.03%
PROTAC IDO1 Degrader-1
IDO1, DC50: 2.84 μM
IDO1, IC50: 1.07 μM
  99.00%
PCC0208009  
IDO, IC50: 4.52 nM (in HeLa cell)
99.08%
IDO5L  
IDO, IC50: 67 nM
IDO, IC50: 19 nM (in HeLa cell)
99.89%
IDO2-IN-1
IDO1, IC50: 411 nM
IDO2, IC50: 112
 98.86%
IDO1-IN-19
IDO1
  98.52%
IDO1/2-IN-1
IDO1, IC50: 28 nM
IDO2, IC50: 144 nM
 98.06%
BMS-986242
IDO1
  98.85%
IDO-IN-3  
IDO, IC50: 290 nM
IDO, IC50: 98 nM (in HeLa cell)
98.97%
IDO-IN-1  
IDO, IC50: 59 nM
IDO, IC50: 12 nM (in HeLa cell)
98.13%
BMS-978587
IDO-1
  99.92%
IDO-IN-5  
IDO, IC50: 1-10 μM
99.90%
IDO-IN-8  
IDO, IC50: 1-10 μM
99.99%
Coptisine  
IDO, IC50: 6.3 μM
IDO, Ki: 5.8 μM
Palmatine
IDO-1, IC50: 3 μM (HEK 293-hIDO-1)
IDO-1, IC50: 157 μM (rhIDO-1)
  
IDO-IN-6  
IDO, IC50: 1 μM
99.90%
2-Hydrazinobenzothiazole
IDO1, IC50: 8 μM
  99.95%
IDO1 and HDAC1 Inhibitor
IDO1, IC50: 69.0 nM
  
IDO-IN-9  
IDO, IC50: 11 nM
IDO, IC50: 1.8 nM (in Hela cell)
IDO-IN-11  
IDO, IC50: 180 nM
IDO, IC50: 14 nM (in Hela cell)
IDO1-IN-17
IDO1, IC50: 0.44 μM (in hela cells)
  
ZC0101
IDO1, IC50: 0.084 μM
  
MMG-0358
IDO1, IC50: 330 nM
  
CAY10581  
IDO, IC50: 55 nM
Roxyl-9
IDO1
  99.22%
NAMPT/IDO1-IN-1
IDO1, IC50: 233 nM
  
IDO1-IN-21
IDO1, IC50: 0.64 μM
  
IDO1-IN-13
IDO1, IC50: 30 nM
  
NDs-IN-1
IDO-1
  
IDO1/TDO-IN-1
IDO1, Ki: 0.23 μM
  
NU223612
IDO1, Kd: 640 nM
  
1-Isopropyltryptophan
IDO1
  
IDO1-IN-15
IDO1, IC50: 127 nM
  
AT-0174
IDO1, IC50: 0.17 μM
  
IDO1-IN-2
IDO1, IC50: 81 nM
  
IDO1-IN-16
IDO1, IC50: 127 nM
  
IDO1-IN-14
IDO1, EC50: 396.9 nM
  
Linrodostat mesylate
IDO1, IC50: 1.1 nM